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PDF reprints are available upon request to Jennie Leach, jleach@umbc.edu

Peer-Reviewed Manuscripts

Santos-Cancel, M., Simpson, L. W., Leach, J. B., & White, R. J. (2019). Direct, Real-Time Detection of Adenosine Triphosphate Release from Astrocytes in Three-Dimensional Culture Using an Integrated Electrochemical Aptamer-Based Sensor. ACS Chem Neurosci. doi:10.1021/acschemneuro.9b00033

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Ghourichaee SS, EM Powell, JB Leach. (2017) Enhancement of human neural stem cell self-renewal in 3D hypoxic culture. Biotechnology & Bioengineering 114:1096-1106

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Ghourichaee SS, JB Leach. (2016) Synergistic effects of substrate and hypoxia on human neural stem cell proliferation. Journal of Materials Chemistry B 4:3509-3514.

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Balasubramanian S, JA Packard, JB Leach, EM Powell. (2016) Three-dimensional environment sustains morphological heterogeneity and promotes phenotypic progression during astrocyte development. Tissue Engineering 22:885-898.

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Balasubramanian S, EM Powell, JB Leach. (2015) Culturing Neurons, Glia and Progenitor Cells in Three-Dimensional Hydrogels. Neuromethods: Extracellular Matrix, Editors: Jennie B. Leach and Elizabeth Powell, publisher: Springer Protocols, Humana Press, 93: 91-99.

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Neuromethods: Extracellular Matrix, (2015) Editors: Jennie B. Leach and Elizabeth Powell, publisher: Springer Protocols, Humana Press.

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Balasubramanian S, EM Powell, JB Leach. (2015) Investigating Cell-ECM Interactions and ECM Synthesis in Three-Dimensional Hydrogels. Neuromethods: Extracellular Matrix, Editors: Jennie B. Leach and Elizabeth Powell, publisher: Springer Protocols, Humana Press, 93: 101-109.

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Leach JB, MS Shoichet. (2015) Naturally-derived and bioinspired materials. Journal of Materials Chemistry B. 3:7814-7.

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Schoukroun-Barnes LR, S Wagan, J Liu, JB Leach, RJ White. (2013) Biocompatible Hydrogel Membranes for the Protection of RNA Aptamer-Based Electrochemical Sensors. Proceedings of SPIE, SPIE Defense, Security + Sensing, 8719-18.

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Zustiak SP, S Pubill, A Ribeiro, JB Leach. (2013) Hydrolytically degradable poly(ethylene glycol) hydrogel scaffolds as a cell delivery vehicle: Characterization of PC12 cell response. Biotechnology Progress 29:1255-64.

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Zustiak SP, Y Wei, JB Leach. (2013) Protein-hydrogel interactions in tissue engineering: mechanisms and applications. Tissue Engineering Part B: Reviews 19:160-71. 

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Wang L, MA Acosta, JB Leach, R Carrier. (2013) Spatially monitoring oxygen level in 3D microfabricated cell culture systems using optical oxygen sensing beads. Lab on a Chip 13:1586-92.

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Ribeiro A, S Balasubramanian, D Hughes, S Vargo, E Powell, JB Leach. (2013) β1-integrin Cytoskeletal Signaling Regulates Sensory Neuron Response to Matrix Dimensionality. Neuroscience 248:67-78.

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Acosta MA, M Velasquez, K Williams, JM Ross, JB Leach. (2012) Fluorescent silica particles for monitoring oxygen levels in three-dimensional heterogeneous cellular structures. Biotechnology & Bioengineering 106:2663-70.

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Guo D, X Chen, S Vadala, J Leach, Y Kostov, W Bewley,C Kim, M Kim, C Canedy, C Merritt, I Vurgaftman, J Meyer, F Choa. (2012) Neuron Absorption Study and Mid-IR Optical Excitations. Proceedings of SPIE, Photonics West BiOS, 8207G-156.

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Ribeiro A, S Vargo, E Powell, JB Leach. (2012) Substrate three-dimensionality induces elemental morphological transformation of sensory neurons on a physiologic timescale. Tissue Engineering 18:93-102.

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Zustiak S, JB Leach. (2011) Characterization of Protein Release from Hydrolytically Degradable Poly(ethylene glycol) Hydrogels. Biotechnology & Bioengineering 108:197-206.

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Leach JB, AKH Achyuta, S Murthy. (2010) Bridging the Divide Between Neuroprosthetic Design, Tissue Engineering and Neurobiology. Frontiers in Neuroengineering 2:article 18, doi: 10.3389/neuro.16.018.2009

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Zustiak S, R Durbal, JB Leach. (2010) Covalent Incorporation of Cell-Adhesive Peptide Ligands into Poly(ethylene glycol) Hydrogels Influences Physical, Mechanical and Transport Properties. Acta Biomaterialia 6:3404-14.

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Zustiak S, JB Leach. (2010) Hydrolytically Degradable Poly(Ethylene Glycol) Hydrogel Scaffolds with Tunable Degradation and Mechanical Properties. Biomacromolecules 11(5):1348–1357.

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Zustiak S, H Boukari, JB Leach. (2010) Solute Diffusion and Interactions in Cross-Linked Poly(ethylene glycol) Hydrogels Studied by Fluorescence Correlation Spectroscopy. Soft Matter 6:3609-18.

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Reeves R, A Ribeiro, Lombardo L, R Boyer, JB Leach. (2010) Synthesis and enzymatic degradation of carboxymethylcellulose-methacrylate hydrogel cell scaffolds. Polymers MDPI 2(3): 252-264.

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Leach JB, EM Powell. (2010) Understanding hypoxic environments – Biomaterials approaches to neural stabilization and regeneration after ischemia. In Studies in Mechanobiology, Tissue Engineering and Biomaterials, Vol 2: Biomaterials as Stem Cell Niche, 247–274.

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Williams C, J Liao, EM Joyce, JB Leach, MS Sacks, JY Wong. (2009) Changes in structural and mechanical properties in decellularized arteries: Implications for vascular tissue engineering. Acta Biomaterialia 5:993-1003.

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Acosta M, P Ymele-Leki, Y Kostov, JB Leach. (2009) Fluorescent microparticles for sensing cell microenvironment oxygen levels within 3D scaffolds. Biomaterials 30:3069-74.

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Sarkar S, BC Isenberg, E Hodis, JB Leach, TA Desai, JY Wong. (2008) Fabrication of a layered microstructured polycaprolactone construct for 3-D tissue engineering. J Biomater Sci Polym Edn 19:1347-1362.

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Leach JB, XQ Brown, JG Jacot, PA DiMilla, JY Wong. (2007) Neurite outgrowth and branching of PC12 cells on very soft substrates sharply decreases below a threshold of substrate rigidity. Journal of Neural Engineering 4:26-34.

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Koester S, JB Leach, B Struth, T Pfohl, JY Wong. (2007) Visualization of type I collagen self-assembly induced by tunable pH gradients. Langmuir 23:357-359.

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Leach JB (2006). Tissue-Engineered Peripheral Nerve. In: Encyclopedia of Biomedical Engineering, editor: Metin Akay, publisher: Wiley, 6: 3568-3578.

Leach JB, CE Schmidt (2005). Characterization of protein release from photocrosslinkable hyaluronic acid-polyethylene glycol hydrogels. Biomaterials 26:125-135.

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Leach, JB, JB Wolinsky, P Stone, JY Wong. (2005) Crosslinked alpha-elastin biomaterials: Towards a processable elastin mimetic scaffold. Acta Biomaterialia 1:155-164.

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Wong JY, JB Leach, XQ Brown (2004). Balance of chemistry, topography, and mechanics at the cell-biomaterial interface: Issues and challenges for assessing the role of substrate mechanics on cell response. Surface Science 570:119-133.

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Leach JB, KA Bivens, CN Collins, CE Schmidt (2004). Development of photocrosslinked hyaluronic acid-polyethylene glycol-peptide composite hydrogels for soft tissue engineering. Journal of Biomedical Materials Research 70A:74-82.

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Baier Leach J*, CE Schmidt (2004). Hyaluronan. In: Encyclopedia of Biomaterials and Biomedical Engineering, editors: GE Wnek, GL Bowlin, publisher: Marcel Dekker, p. 779-89.

Schmidt CE, J Baier Leach* (2003). Neural tissue engineering: strategies for repair and regeneration. Annual Review of Biomedical Engineering 5:293-347.

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Baier Leach J*, KA Bivens, CW Patrick, Jr., CE Schmidt (2003). Photocrosslinked hyaluronic acid hydrogels: natural, biodegradable tissue engineering scaffolds. Biotechnology & Bioengineering 82:578-89.

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Fischbeck JA, JM Baier*, R Akella, D Hern-Anderson, CE Schmidt (2001). Genetic modification of alpha-Gal expression in xenogeneic endothelial cells yields a complex immunological response. Tissue Engineering 7:743-56.  

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Schmidt CE, JM Baier* (2000). Acellular vascular tissues: natural biomaterials for tissue repair and tissue engineering. Biomaterials 21:2215-31.

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*Jennie B. Leach is also listed as J.M. Baier and J. Baier Leach.