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PDF reprints are available upon request to Jennie Leach, jleach@umbc.edu

Peer-Reviewed Manuscripts

Schmidt CE, JM Baier* (2000). Acellular vascular tissues: natural biomaterials for tissue repair and tissue engineering. Biomaterials 21:2215-31.

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Wong JY, JB Leach, XQ Brown (2004). Balance of chemistry, topography, and mechanics at the cell-biomaterial interface: Issues and challenges for assessing the role of substrate mechanics on cell response. Surface Science 570:119-133.

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Schoukroun-Barnes LR, S Wagan, J Liu, JB Leach, RJ White. (2013) Biocompatible Hydrogel Membranes for the Protection of RNA Aptamer-Based Electrochemical Sensors. Proceedings of SPIE, SPIE Defense, Security + Sensing, 8719-18.

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Leach JB, AKH Achyuta, S Murthy. (2010) Bridging the Divide Between Neuroprosthetic Design, Tissue Engineering and Neurobiology. Frontiers in Neuroengineering 2:article 18, doi: 10.3389/neuro.16.018.2009

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Williams C, J Liao, EM Joyce, JB Leach, MS Sacks, JY Wong. (2009) Changes in structural and mechanical properties in decellularized arteries: Implications for vascular tissue engineering. Acta Biomaterialia 5:993-1003.

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Zustiak S, JB Leach. (2011) Characterization of Protein Release from Hydrolytically Degradable Poly(ethylene glycol) Hydrogels. Biotechnology & Bioengineering 108:197-206.

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Leach JB, CE Schmidt (2005). Characterization of protein release from photocrosslinkable hyaluronic acid-polyethylene glycol hydrogels. Biomaterials 26:125-135.

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Simpson, LW, GL Szeto, H Boukari, TA Good, JB Leach. (2020) Collagen hydrogel confinement of Amyloid-β (Aβ) accelerates aggregation and reduces cytotoxic effects. Acta Biomaterialia 112:164-173.

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Zustiak S, R Durbal, JB Leach. (2010) Covalent Incorporation of Cell-Adhesive Peptide Ligands into Poly(ethylene glycol) Hydrogels Influences Physical, Mechanical and Transport Properties. Acta Biomaterialia 6:3404-14.

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Leach, JB, JB Wolinsky, P Stone, JY Wong. (2005) Crosslinked alpha-elastin biomaterials: Towards a processable elastin mimetic scaffold. Acta Biomaterialia 1:155-164.

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Balasubramanian S, EM Powell, JB Leach. (2015) Culturing Neurons, Glia and Progenitor Cells in Three-Dimensional Hydrogels. Neuromethods: Extracellular Matrix, Editors: Jennie B. Leach and Elizabeth Powell, publisher: Springer Protocols, Humana Press, 93: 91-99.

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Leach JB, KA Bivens, CN Collins, CE Schmidt (2004). Development of photocrosslinked hyaluronic acid-polyethylene glycol-peptide composite hydrogels for soft tissue engineering. Journal of Biomedical Materials Research 70A:74-82.

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Santos-Cancel, M., Simpson, L. W., Leach, J. B., & White, R. J. (2019). Direct, Real-Time Detection of Adenosine Triphosphate Release from Astrocytes in Three-Dimensional Culture Using an Integrated Electrochemical Aptamer-Based Sensor. ACS Chem Neurosci. doi:10.1021/acschemneuro.9b00033

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Neuromethods: Extracellular Matrix, (2015) Editors: Jennie B. Leach and Elizabeth Powell, publisher: Springer Protocols, Humana Press.

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Ghourichaee SS, EM Powell, JB Leach. (2017) Enhancement of human neural stem cell self-renewal in 3D hypoxic culture. Biotechnology & Bioengineering 114:1096-1106

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Sarkar S, BC Isenberg, E Hodis, JB Leach, TA Desai, JY Wong. (2008) Fabrication of a layered microstructured polycaprolactone construct for 3-D tissue engineering. J Biomater Sci Polym Edn 19:1347-1362.

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Acosta M, P Ymele-Leki, Y Kostov, JB Leach. (2009) Fluorescent microparticles for sensing cell microenvironment oxygen levels within 3D scaffolds. Biomaterials 30:3069-74.

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Acosta MA, M Velasquez, K Williams, JM Ross, JB Leach. (2012) Fluorescent silica particles for monitoring oxygen levels in three-dimensional heterogeneous cellular structures. Biotechnology & Bioengineering 106:2663-70.

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Fischbeck JA, JM Baier*, R Akella, D Hern-Anderson, CE Schmidt (2001). Genetic modification of alpha-Gal expression in xenogeneic endothelial cells yields a complex immunological response. Tissue Engineering 7:743-56.  

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Baier Leach J*, CE Schmidt (2004). Hyaluronan. In: Encyclopedia of Biomaterials and Biomedical Engineering, editors: GE Wnek, GL Bowlin, publisher: Marcel Dekker, p. 779-89.

Zustiak SP, S Pubill, A Ribeiro, JB Leach. (2013) Hydrolytically degradable poly(ethylene glycol) hydrogel scaffolds as a cell delivery vehicle: Characterization of PC12 cell response. Biotechnology Progress 29:1255-64.

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Zustiak S, JB Leach. (2010) Hydrolytically Degradable Poly(Ethylene Glycol) Hydrogel Scaffolds with Tunable Degradation and Mechanical Properties. Biomacromolecules 11(5):1348–1357.

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Simpson, LW, GL Szeto, H Boukari, TA Good, JB Leach. (2020) Impact of four common hydrogels on Amyloid-β (Aβ) aggregation and cytotoxicity: Implications for 3D models of Alzheimer’s disease. Accepted on July 23, 2020 to ACS Omega.

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Balasubramanian S, EM Powell, JB Leach. (2015) Investigating Cell-ECM Interactions and ECM Synthesis in Three-Dimensional Hydrogels. Neuromethods: Extracellular Matrix, Editors: Jennie B. Leach and Elizabeth Powell, publisher: Springer Protocols, Humana Press, 93: 101-109.

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Henry RJ, Ritzel RR, Barrett JP, Doran SJ, Jiao Y, Meadows VE, Leach JB, Szeto GL, Stoica BA, Faden AI, Loane DJ. (2020) Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits. Journal of Neuroscience 40(14):2960-2974.

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Leach JB, MS Shoichet. (2015) Naturally-derived and bioinspired materials. Journal of Materials Chemistry B. 3:7814-7.

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Schmidt CE, J Baier Leach* (2003). Neural tissue engineering: strategies for repair and regeneration. Annual Review of Biomedical Engineering 5:293-347.

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Leach JB, XQ Brown, JG Jacot, PA DiMilla, JY Wong. (2007) Neurite outgrowth and branching of PC12 cells on very soft substrates sharply decreases below a threshold of substrate rigidity. Journal of Neural Engineering 4:26-34.

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Guo D, X Chen, S Vadala, J Leach, Y Kostov, W Bewley,C Kim, M Kim, C Canedy, C Merritt, I Vurgaftman, J Meyer, F Choa. (2012) Neuron Absorption Study and Mid-IR Optical Excitations. Proceedings of SPIE, Photonics West BiOS, 8207G-156.

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Baier Leach J*, KA Bivens, CW Patrick, Jr., CE Schmidt (2003). Photocrosslinked hyaluronic acid hydrogels: natural, biodegradable tissue engineering scaffolds. Biotechnology & Bioengineering 82:578-89.

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Simpson, LW, TA Good, JB Leach. (2020) Protein folding and assembly in confined environments: Implications for protein aggregation in biomaterial scaffolds and tissues. Biotechnology Advances 42:107573.

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Zustiak SP, Y Wei, JB Leach. (2013) Protein-hydrogel interactions in tissue engineering: mechanisms and applications. Tissue Engineering Part B: Reviews 19:160-71. 

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Zustiak S, H Boukari, JB Leach. (2010) Solute Diffusion and Interactions in Cross-Linked Poly(ethylene glycol) Hydrogels Studied by Fluorescence Correlation Spectroscopy. Soft Matter 6:3609-18.

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Wang L, MA Acosta, JB Leach, R Carrier. (2013) Spatially monitoring oxygen level in 3D microfabricated cell culture systems using optical oxygen sensing beads. Lab on a Chip 13:1586-92.

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Ribeiro A, S Vargo, E Powell, JB Leach. (2012) Substrate three-dimensionality induces elemental morphological transformation of sensory neurons on a physiologic timescale. Tissue Engineering 18:93-102.

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Ghourichaee SS, JB Leach. (2016) Synergistic effects of substrate and hypoxia on human neural stem cell proliferation. Journal of Materials Chemistry B 4:3509-3514.

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Reeves R, A Ribeiro, Lombardo L, R Boyer, JB Leach. (2010) Synthesis and enzymatic degradation of carboxymethylcellulose-methacrylate hydrogel cell scaffolds. Polymers MDPI 2(3): 252-264.

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Balasubramanian S, JA Packard, JB Leach, EM Powell. (2016) Three-dimensional environment sustains morphological heterogeneity and promotes phenotypic progression during astrocyte development. Tissue Engineering 22:885-898.

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Leach JB (2006). Tissue-Engineered Peripheral Nerve. In: Encyclopedia of Biomedical Engineering, editor: Metin Akay, publisher: Wiley, 6: 3568-3578.

Jiao Y, Faden A, Sabirzhanov B, Stoica B, Szeto GL, Leach J. (2020) Transcriptional profiling predicts behavioral performance in experimental mouse model of traumatic brain injury (TBI). Journal of Immunology 204(1 Supplement):75.17.

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Leach JB, EM Powell. (2010) Understanding hypoxic environments – Biomaterials approaches to neural stabilization and regeneration after ischemia. In Studies in Mechanobiology, Tissue Engineering and Biomaterials, Vol 2: Biomaterials as Stem Cell Niche, 247–274.

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Koester S, JB Leach, B Struth, T Pfohl, JY Wong. (2007) Visualization of type I collagen self-assembly induced by tunable pH gradients. Langmuir 23:357-359.

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Ribeiro A, S Balasubramanian, D Hughes, S Vargo, E Powell, JB Leach. (2013) β1-integrin Cytoskeletal Signaling Regulates Sensory Neuron Response to Matrix Dimensionality. Neuroscience 248:67-78.

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*Jennie B. Leach is also listed as J.M. Baier and J. Baier Leach.